9 people (BA, CE , HL, JD, JJ, KS, KW, MA, RL) participated in up to 4 active working group meetings. 

The Project Management Working Group discussed and responded to a group that has volunteered to work on a Chinese translation of our developing GRADE Ontology. We now have the potential to share our work in French, Spanish, Portuguese, Norwegian and Chinese.

The Setting the Scientific Record on FHIR Working Group worked on development of a common solution across converter tools  (including MAGICapp and GRADEpro) to autogenerate the section narrative content for comparative evidence reports.   

The CQL Development Working Group(a CDS EBMonFHIR sub-WG) worked with SRDR to plan how they will bulk load a project on the FEvIR Platform and generally discussed API interactions and resource identity management (FOI's).

The Statistics Terminology Working Group reviewed the 5 terms open for vote last week and made the following revisions based on feedback received from the expert working group:

Terms approved by unanimous vote:
  - absolute value
  - area under the ROC curve

Terms will negative votes and feedback:
  - quantile
    A negative vote with a comment "Can we add information about quartiles" and we added more to the comment for application, and sent it back out for vote

  - partial area under the ROC curve
    A negative vote with a comment saying to add "and/or range of possible values for the true positive rate" which we added to the end of the definition and correct an issue with the comment for application to now say "1-specificity" instead of "1-sensitivity" and we sent it back out for vote.

We corrected the term "area under the ROC curve" to say "1-specificity" instead of "1-sensitivity".

- percentile
  Added an alternative term "centile" and "%ile"
  And opened it for vote

- decile
  Added a defintion and comment for application for it based on the percentile comment.
  And opened it for vote

- quartile
  Added a definition for it and comment for application for it
  And opened it for vote

- chi square for homogeneity
  Added a definition
  Added an alternative term "chi-square test of homogeneity"

We will need to reach out to a previous negative voter on "area under the value-by-time curve" and get them to vote on the term again with more information about the change they would like to see.

There are currently 8 statistic terms open for vote, (if you have voted on any of these terms before, please vote again):

Term
Definition
Alternative Terms
(if any)
Comment for application
(if any)
A statistic that represents the value for which the number of data points at or below it constitutes a specific portion of the total number of data points.

Quantile is a type of statistic but not used without specification of the portion it represents. For example, one may report a fortieth percentile (40%ile) but one does not report a percentile without specification of which percentile. One may report a first quartile (25%ile), second quartile (median or 50%ile), or third quartile (75%ile) but one does not report a quartile without specification of which quartile.

A quantile in which the specific portion of the number of data points is expressed as a percentage.
  • centile
  • %ile

Quantile is defined as a statistic that represents the value for which the number of data points at or below it constitutes a specific portion of the total number of data points.

Percentile is a type of statistic but not used without specification of the portion it represents. For example, one may report a fortieth percentile (40%ile) but one does not report a percentile without specification of which percentile. 40% of the data is at or below the 40%ile.

A quantile in which the specific portion of the number of data points is expressed as a number of tenths.

Quantile is defined as a statistic that represents the value for which the number of data points at or below it constitutes a specific portion of the total number of data points.

Decile is a type of statistic but not used without specification of the portion it represents. For example, one may report a fourth decile but one does not report a decile without specification of which decile. 40% of the data is at or below the fourth decile.

A quantile in which the specific portion of the number of data points is expressed as a number of fourths.

Quantile is defined as a statistic that represents the value for which the number of data points at or below it constitutes a specific portion of the total number of data points.

Quartile is a type of statistic but not used without specification of the portion it represents. For example, one may report a third quartile but one does not report a quartile without specification of which quartile. 75% of the data is at or below the third quartile. The second quartile is also called the median.

A measure of heterogeneity, based on the chi-square statistic, for reporting an analytic finding regarding whether two or more multinomial distributions are equal, accounting for chance variability.
  • chi-square test of homogeneity
  • chi2 heterogeneity statistic

A measure of heterogeneity is defined as statistic that represents the variation or spread among values in the set of estimates across studies.

An area under the curve where the curve is the true positive rate and the range of interest is the false positive rate.
  • AUC
  • AUROC
  • area under the receiver operating characteristic curve
  • c-statistic
  • C-statistic
  • Harrell's C
  • concordance index
  • concordance statistic

ROC stands for Receiver Operating Characteristic. The area under the ROC curve is used to assess the performance of a classifier used to distinguish between two or more groups. Another term for true positive rate is sensitivity and another term for false positive rate is 1-specificity.

The c-statistic is the area under the ROC curve calculated with the full range of possible values for true positive rate and false positive rate. Another interpretation of the c-statistic is similar without explicitly referencing the ROC curve: "The C statistic is the probability that, given 2 individuals (one who experiences the outcome of interest and the other who does not or who experiences it later), the model will yield a higher risk for the first patient than for the second. It is a measure of concordance (hence, the name “C statistic”) between model-based risk estimates and observed events. C statistics measure the ability of a model to rank patients from high to low risk but do not assess the ability of a model to assign accurate probabilities of an event occurring (that is measured by the model’s calibration). C statistics generally range from 0.5 (random concordance) to 1 (perfect concordance)." (JAMA. 2015;314(10):1063-1064. doi:10.1001/jama.2015.11082)

An area under the curve where the curve is the true positive rate and the range of interest is a specified portion of the range of possible values for the false positive rate and/or range of possible values for the true positive rate.

Area under the ROC curve is defined as an area under the curve where the curve is the true positive rate and the range of interest is the false positive rate. ROC stands for Receiver Operating Characteristic. The area under the ROC curve is used to assess the performance of a classifier used to distinguish between two or more groups. Another term for true positive rate is sensitivity and another term for false positive rate is 1-specificity.

An area under the curve where the curve is the repeated measures of a variable over time and the domain of interest is time.
  • area under the value-time curve
  • area under the value vs. time curve
  • area under the value versus time curve

The area under the value-by-time curve is used for pharmacokinetics, pharmacodynamics, and physiological monitoring.


Releases on the FEvIR Platform:

The Fast Evidence Interoperability Resources (FEvIR) Platform is available for use now, but is “pre-release”.  The current version is 0.213.0 (April 15, 2024). Viewing resources is open without login.  Signing in is free and required to create content (which can then only be edited by the person who created the content).

Release 0.213.0 (April 15, 2024) adds an alert of "All resources successfully submitted." to the bulk JSON entry page  and automatically generates section narrative from the referenced entry Resources for Comparative Evidence Reports generated by Converter Tools. The citation element now uses markdown features when using the citation element of RelatedArtifact datatype.

The Computable Publishing®: Comparative Evidence Report Authoring Tool version 0.20.0 (April 15, 2024) creates and displays a Composition Resource with a ComparativeEvidenceReport Profile.

Release 0.20.0 (April 15, 2024) provides "Generate Natural Language Summary" buttons in all sections to automatically generate a section narrative from the referenced entry (or focus) Resource, and supports immediate saving of changes to referenced Resources.

Computable Publishing®: MAGIC-to-FEvIR Converter version 0.15.0 (April 15, 2024) converts data from a MAGICapp JSON file (demo files available) to FEvIR Resources in FHIR JSON.

Release 0.15.0 (April 15, 2024) creates statistic.description content for each of the Evidence.statistic instances generated.

Quote for thought: Spread love everywhere you go. Let no one ever come to you without leaving happier. -Saint Teresa of Calcutta


 

 

To get involved or stay informed: HEvKA Project Page on FEvIR Platform, HEvKA Project Page on HL7 Confluence, or join any of the groups that are now meeting in the following weekly schedule:

Weekly Meeting Schedule and Link:

 

Day

Time (Eastern)

Team

Monday 

8-9 am 

Project Management

Monday

9-10 am

Setting the Scientific Record on FHIR WG

Monday 

10-11 am

CQL Development WG (a CDS EBMonFHIR sub-WG)

Monday 

2-3 pm 

Statistic Terminology WG

Tuesday

9-10 am

Measuring the Rate of Scientific Knowledge Transfer WG

Tuesday 

2-3 pm 

StatisticsOnFHIR WG (a CDS EBMonFHIR sub-WG)

Tuesday

3-4 pm

Ontology Management WG

Wednesday

8-9 am 

Funding the Ecosystem Infrastructure WG

Wednesday

9-10 am 

Communications(Awareness, Scholarly Publications) WG

Thursday

8-9 am

EBM Implementation Guide WG (a CDS EBMonFHIR sub-WG)

Thursday

9-10 am

Computable EBM Tools Development WG

Friday

9-10 am 

Risk of Bias Terminology WG

Friday

10-11 am 

GRADE Ontology WG

Friday

12-1 pm

Project Management

 

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Research and Analysis Manager, Computable Publishing LLC

 

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